Amidines are compounds with an NCN structure, which can be found in many biologically active molecules.



Amidines have so far been difficult to synthesize, especially without substituents on nitrogen. AlzChem research has found a new synthesis process for amidines that adds another method to the toolbox of active ingredient chemistry. They credit the development to a combination of their leadership in NCN chemistry, expertise in the synthesis of organomagnesium Grignard compounds and know-how in silane reactions. The new method was published in the journal SYNLETT (Issue 2017; 28(12): 1437-1440); patents are pending.

You could also get more details at their presentation at Chemspec Europe, the 33rd Int’l Exhibition for Fine and Specialty Chemicals in Cologne Germany, which will be held on 20 and 21 June.